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Modern research methodologies emphasize the value of comprehensive data analysis1. Scholars utilize advanced analytical frameworks2 to examine complex research questions systematically3. This methodology facilitates thorough investigation of multiple variables simultaneously, enhancing research quality and reliability4.

12
3
1
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3
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Empirical research methods and statistical analysis

Sarah J. Martinez

12
3
2020 • 142 citations

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Paper TitleLead AuthorDate AddedLast ReviewedKeywordsSource
Machine Learning Applications in Early Cancer Detection
Patel, et al.Today5 minutes ago
oncologymachine learningearly detection
Source
Neural Network Models for Predicting Patient Outcomes in ICU
Anderson, et al.1w ago3d ago
critical careneural networkspredictive modeling
Source
Deep Learning for Medical Image Analysis in Radiology
Kumar, et al.2d ago1h ago
radiologydeep learningmedical imaging
Source
Transformer Architectures for Medical Diagnosis
Chen, et al.YesterdayJust now
medical imagingtransformersdiagnosis
Source
Natural Language Processing for Clinical Note Analysis
Rodriguez, et al.5d ago2d ago
nlpclinical noteselectronic health records
Source
Reinforcement Learning for Personalized Treatment Recommendations
Thompson, et al.1w agoYesterday
personalized medicinereinforcement learningtreatment
Source
Biomarker Discovery Using Machine Learning in Precision Medicine
Singh, et al.3d ago1d ago
biomarkersprecision medicineml
Source
Federated Learning for Multi-Institutional Medical Research
Martinez, et al.4d ago2d ago
federated learningmulti-institutionalprivacy
Source
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12 pages
REWIND trial — cardiovascular outcomes
Added 2d ago · 3 highlights · 1 note
Year: 2024Design: RCTJournal: NEJMPMID: 40123456+ more
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semaglutideMACET2DASCVD

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GLP‑1 MACE hazard ratio
RCT2020–2025CardiologyHigh relevance
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Meta-analysis: GLP‑1 RAs & MACE outcomes (2024)
“…consistent reduction in 3‑point MACE across CVOTs with low heterogeneity…”
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SELECT trial: semaglutide in obesity
…reduced composite CV outcomes in adults with overweight/obesity…
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LEADER trial: liraglutide CV outcomes
…lower risk of major adverse CV events vs placebo…
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Sepsis-3: Consensus Definitions for Sepsis and Septic Shock
Singer et al. · JAMA 2016
Clinical criteria
Surviving Sepsis Campaign: International Guidelines
Evans et al. · Intensive Care Med 2021
Guidelines
Lactate Clearance as a Target in Septic Shock
Jones et al. · JAMA 2010
Outcomes
Paper
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Sepsis-3: Definitions for Sepsis and Septic Shock
Citations: 12k+
Abstract

Sepsis is defined as life‑threatening organ dysfunction caused by a dysregulated host response to infection [1].

Operationally, organ dysfunction is captured by an acute change in SOFA score, and bedside screening can leverage qSOFA in out‑of‑ICU settings [1] [2].

Key idea: standardize detection (SOFA/qSOFA) and pair with timely resuscitation + lactate monitoring for better outcomes.

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[1] Singer et al., 2016JAMA
[2] Evans et al., 2021SSC
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Use Sepsis‑3 criteria (SOFA ≥ 2) for diagnosis; qSOFA is a fast screen outside ICU. Track lactate trends during resuscitation and document rationale for escalation.
[1][2]
Citations used
[1] Singer, M. et al. (2016) — Sepsis‑3 definitions.
[2] Evans, L. et al. (2021) — Surviving Sepsis Campaign.
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